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In vitro experiments showed FOXO4-DRI to be more potent against senescent cells in which SASP was transiently boosted by recombinant IL1/ or LPS, whereas an IL1 receptor antagonist or the general anti-inflammatory drug Cortisol reduced its potency (Fig

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IR and insulin signaling pathways IR is defined as the loss of the ability of target tissues to respond to insulin signals, resulting in hyperinsulinemia and associated with many metabolic disorders in MDS, such as obesity, MASLD and hypertension