In colon cancer models, it shut down tumor cell mitosis and triggered apoptosis in cancer cells
Dawe, G
Botanical Rev
DNA recognition Next, the DNA binding properties of the Cu 3 -TC complexes were investigated using 1) a competition assay with the DNA intercalating fluorophore ethidium bromide (EtBr), and 2) quenching experiments using limited bound fluorophores Hoechst-34580 (Hoechst) and methyl green (MG) 20 , which bind in the minor and major grooves of DNA, respectively (Fig
MOTS-c is a mitochondrial-derived peptide that activates AMPK through direct mitochondrial signaling and nuclear translocation under metabolic stress, whereas metformin activates AMPK indirectly by inhibiting Complex I of the mitochondrial electron transport chain, and AICAR mimics AMP to trick the cell into AMPK activation
Pancreatitis (more common for those who have had bariatric surgery) On side effects: The most common side effects seen in patients are GI (gastrointestinal) symptoms, including nausea, vomiting, constipation and/or diarrhea
