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doi: 10.1016/j.redox.2021.102041 19 BaH

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That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed

This is often mild and short-lived, lasting for no longer than 24 hours