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D.HinkleC

In summary, the three peptides play multiple important roles in the human body, and are of great significance for maintaining normal physiological functions and health status of the body

Dieckhaus CM, Fernandez-Metzler CL, King R, Krolikowski PH, Baillie TA

The Pro-Gly-Pro (PGP) addition is a stabilising motif that protects against enzymatic degradation and increases half-life

In practice, many researchers use the 28-day mark as a hard cutoff

Translocates from mitochondria to the nucleus under metabolic stress, where it regulates nuclear gene expression related to mitochondrial biogenesis, antioxidant responses, proteostasis, and metabolic adaptation