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In addition, those who have COMT Val/Val genotype (genotype with greater enzyme expression) were associated with a significantly increased risk of UF as compared to those with Val/Met genotype (intermediate expression) and Met/Met genotype (low expression), which could have explained the higher risk of UF in African American women (47% having Val/Val genotype) ( In vitro study showed that the ability of green tea extract in inhibiting the proliferation of leiomyoma cells is in part due to the potential of EGCG in reducing the expression of the COMT enzyme (Zhang et al., 2014)

Vitamin C reduces oxidative stress damage in PCOS, through upregulating antioxidant enzyme expression

10.1016/0006-291X(88)90255-0

Since the ROS are products of XOR reaction (the final step in UA synthesis) the increased expression and/or activity XOR leads to ROS generation and increase in their cellular content

Some feel better within 2-3 weeks, others need several months

Check Underlying Conditions: Pair your injections with treatments for any co-existing health issues for the best outcomes