Apart from the local adverse effects of these agents, the important limitation is the localization of their effect to the site of application alone
R.HimathiM
Copper bound to thiols and other groups can cause protein modifications and the formation of altered self-protein with new antigens, which, previously unknown to the immune system, will become the target of an autoimmune reaction, activating B cells with the participation of Th lymphocytes [233,244,245]
Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., & Kolega, Z
During or immediately after treatment , about 30% of clients report feeling more alert and energized
Tissue Eng B Rev 17:165176 Lovric-Bencic M, Sikiric P, Hanzevacki JS, Seiwerth S, Rogic D, Kusec V, Aralica G, Konjevoda P, Batelja L, Blagaic AB (2004) Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse