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Liver inflammation (hepatitis) is operationally defined as a constellation of changes that represent a severe and generalized liver reaction and would require multiple diagnostic terms to adequately characterize (Figure 70)

Am J Physiol Integr Comp Physiol 315:R284R295

However, before getting into the specifics, lets first define hyperpigmentation and discuss its causes

10.2174/0929867321666131228204246 66 KunzS.TegederI.CosteO.MarianC.PfenningerA.CorveyC.et al

The inhibition of H3R via H3R antagonists enhances histamine release, thereby suppressing the neuroinflammatory effects of microglia and preventing dopaminergic neuronal degeneration [58,61]