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Numbness or tingling (often described as pins and needles) typically shows up in your hands and feet first

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It participates in over 500 enzymatic reactions and is essential for energy production, DNA repair, and cellular signaling

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On the physical side, you might notice constant tiredness that doesn't improve with rest, heavy legs during workouts, shortness of breath on efforts that shouldn't wind you, pale skin, and a need for frequent napping