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Metabolic-dysfunction and obesity-pathway preclinical investigations

78 It was found that reduced GPX4 expression leads to increased lipid ROS levels and activation of ferroptosis

The long-term effects are debated and include valvular stenosis, stroke, and kidney disease [328]

A landmark randomized, cross-over clinical trial published in the International Journal of Clinical Nutrition & Dietetics by [Fanelli et al

It accelerates tendon fibroblast outgrowth, increases cell survival under stress, and promotes cell migration, likely through the activation of the FAK-paxillin pathway

In Table 1, we summarized key MDSC-associated checkpoints, detailing the signaling pathways involved, mechanisms by which these checkpoints mediate immunosuppression, and potential drug candidates targeting these pathways