A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion, which can: Selectively induce apoptosis in senescent cells in vitro and in vivo Neutralize phenotypical and liver chemotoxicity by Doxorubicin Restore fitness, hair density and renal function in fast and naturally aged mice Acknowledgments We thank Felicity Chandler for assistance with IHC experiments, Anne Drabbe and David Brouwer for assistance with in vivo experiments, Yanto Ridwan for assistance with CT and IVIS imaging, Yvette van Loon for genotyping of the mice, Martin Viertler for initial NMR experiments, Boudewijn Burgering for fruitful discussions and Petra de Keizer-Burger for critical reading of the manuscript
For those aiming to treat specific injuries or inflammation, the dosage may be gradually increased
The answer depends on what you are trying to fix
I., & Ryzhak, G
Other DSIP Indications In addition to the already mentioned indications, DSIP proves to be a promising tool for stress manifestations, as it is excellent at reducing the manifestations of acute and long-term stress
- Typical Protocol: CJC-1295 with DAC: 2 mg once per week
