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Yes, older adults or people with conditions like pernicious anemia may need more time to absorb B12 properly

10.1016/j.biopha.2020.111036 236 WuY.DuanZ.QuL.LiuY.MaX.FanD

When At GSTU19 was tested with ISSG, tight and stoichiometric binding was determined (Table 2 and Supplementary Figure S5)