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1 Introduction Bone defects are commonly encountered in clinical practice and can arise from various causes, including trauma (e.g., fractures), age-related bone loss (e.g., osteoporosis), infections (e.g., osteomyelitis and periodontitis), cancer (e.g., surgical resection), genetic diseases (e.g., inherited bone marrow failure syndrome), and congenital defects (e.g., cleft palate)

& Fisher, R

Karacier tarafndan retilir ve vcuttaki birok srete rol oynar

Pang SY, Ho PW, Liu HF, Leung CT, Li L, Chang EE, et al

Dahlin, D

Most carriers of the mutation suffer microinfarcts and brain hemorrhages in their twenties, leading to paralysis, dementia, and death in young adults, with an average life expectancy of 30 years 2,3,4,5,6