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The REDEFINE 2 trial in patients with type 2 diabetes showed CagriSema achieved HbA1c levels of 6.5% or below in 73.5% of participants

This is likely to be an issue in G6PD-deficient individuals because an inability to maintain endothelial homeostasis has been linked to both acute and chronic inflammatory endothelial activation and has relevance to pathologies as diverse as cardiovascular disease and sepsis

"Continued treatment with tirzepatide for maintenance of weight reduction." JAMA

doi: 10.1111/andr.2015.3.issue-3 88 SafarinejadM

Ricciardi MR, McQueen T, Chism D, Milella M, Estey E, Kaldjian E, Sebolt-Leopold J, Konopleva M, Andreeff M

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