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Since SARS-CoV-2 activates mitochondrial ROS-mediated feedback loops that produce long-term changes in the redox status and endothelial function of the host, leading to cardiovascular disease and lung injury (Chang et al., 2021), and endothelial cells are key players in inflammatory pathologies, such as acute respiratory distress syndrome, thrombosis, and atherosclerosis

Restoring NAD+ levels improves mitochondrial function, redox balance, and hepatocellular homeostasis

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Swinnen JV, Dehairs J, Talebi A