In the initial larger, higher resolution, dataset of Cagri-CTR-Gs ( N = 1), density was observed for the proximal region of the conjugated lipid at the peptide N-terminus that was consistent regardless of peptide conformation (bypass or CT-like) and supports modelling the Glu linker and a short segment of acyl chain in a different orientation to that observed in the AMY 1 R complex (Figs
It usually means either the root cause needs further investigation (which is where functional lab testing becomes valuable) or the protocol needs adjustment
References Sikiric P, Seiwerth S, Rucman R, et al
If those appear, the reaction is something more serious than the copper uglies and you should stop the product immediately and consult a dermatologist
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