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While the theoretical underpinnings of the "15-minute city" are rooted in principles of proximity and inclusivity, practical implementation requires data-driven approaches

This cascade also appears to intersect with mitochondrial and ER stress pathways, where redox imbalance and unfolded protein responses converge-mechanisms mechanistically reminiscent of those implicated in neurodegeneration

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Am J Clin Nutr 86(4):10821093

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Conventional thinking posits that a primary defect in adaptive immunity promotes recruitment and entry of peripherally activated lymphocytes into the CNS across a disrupted bloodbrain barrier where a complex cascade of autoimmune/inflammatory processes culminates in edema, and destruction of myelin, axons and oligodendrocytes (for detailed reviews see Dendrou et al., 2015