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Pharmacol Rep 65(4):884890 Chang JT, Liang YJ, Hsu CY, Chen CY, Chen PJ, Yang YF et al (2017) Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells

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Most cases develop slowly over years as the spine accumulates wear-and-tear changes: discs lose height, ligaments thicken, joints develop arthritis, and bone spurs (osteophytes) form

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