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Reviewers also note more long-term clinical trials are needed to confirm the full potential

In the context of bone and cartilage regeneration, MenSCs cultured in osteogenic induction medium for 21 days presented marked morphological changes, along with significantly upregulated expression of key osteogenic markers such as alkaline phosphatase (ALP), secreted phosphoprotein 1 (SPP1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP) (Skliut et al., 2021)

However, unlike PTL DC , PTL ACair did not show such good effects after the prolonged exposure

Sousa De Almeida, M., Rothen-Rutishauser, B., Mayer, M