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Semaglutide (Wegovy) produces about 15-17% weight loss

Recently, a hybrid model (cuprizone autoimmune encephalitis or CAE) combining the myelin-toxic effects of cuprizone (Zirngibl et al., 2022) together with an immune stimulation identical to EAE but without extrinsic myelin peptides, provided proof-of-principle for the notion that a primary biochemical dysmyelination can result in a very typical inflammatory demyelinating white matter lesion in an immune-stimulated host (Caprariello et al., 2018)

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If we find an unexpected beneficial effect of vitamin B 12 on the results of this test, the DSMB will consider stopping the trial