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However, when removing the tumor, it is difficult for the surgeon to completely remove the cancerous mass in all of its entirety without touching the surrounding healthy tissue

Decreasing the liberation of glutamate from the glutathione cycle leads to decreased cortical neuron glutamate, while decreasing the utilization of glutamate increases total glutamate by about 25%

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consistent with radiation-triggered cGAS-cGAMP-STING activation and downstream inflammatory programs, these myeloid changes can amplify inflammatory signaling and promote profibrotic remodeling, providing a mechanistic bridge between acute immune perturbation and chronic RE progression 56

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