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Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

The deltoid (upper arm) is also an IM site but can be harder to reach on your own

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These intramuscular injections, usually containing cyanocobalamin or methylcobalamin, are administered weekly or monthly as prescribed by a healthcare provider

optional cycling with 6-week breaks between courses

The rate at which the vitamin is absorbed is the primary distinction between B12 injections and infusions