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In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%

While semaglutide offers significant benefits for weight loss and diabetes management, its impact on the gastrointestinal system, including delayed gastric emptying, can interfere with nutrient absorption

Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast

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