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Studies using Arabidopsis roGFP reporter lines that targeted specific cell compartments showed that in most of these compartments, glutathione is maintained in a reduced redox state under non-stress conditions

The inhibition of GLS-1 in vitro decreased the concentration of downstream glutaminase metabolites (glutamate, -ketoglutarate, aspartate, fumarate, and malate) and induced cell death (10, 11)

It's a solubility problem

Because of this, it is a great way to treat skin prone to acne

92 In this mechanism, bacterial GSH is an essential cofactor, and mutants that are defective in GSH biosynthesis cannot inactivate fosfomycin, even though they possess the resistance gene

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