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Although these classical inhibitors show great potential in preclinical research, their clinical translation still faces substantial obstacles, including poor metabolic stability, suboptimal pharmacokinetics, and the critical fact that no anti-ferroptosis drug has yet entered human trials

For example, whether mesangial cell ferroptosis contributes to glomerulosclerosis (a core pathological feature of LN) or if tubular epithelial cell ferroptosis amplifies renal inflammation and fibrosis in LN has not been rigorously characterized

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Waktu terbaik adalah saat perut dalam kondisi optimal untuk penyerapan, biasanya pagi hari atau sebelum tidur