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Meanwhile, the expression of p16 in the glomeruli is linked to the occurrence of proteinuria associated with DN

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This finding highlights not only the key role that mitochondrial metabolism has in modulating response and resistance to TS inhibitors, but the wider opportunity afforded to enhance TS inhibitor-mediated anti-cancer effects by targeting mitochondrial metabolism using metformin or other compounds with similar mitochondrial impact

doi:10.1016/j.envint.2016.08.019 Dzhambov AM

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D.F.-A.s work was supported by funding from the European Union FP7-Euratom-Fission award 323267, Risk, Stem Cells and Tissue KineticsIonising Radiation at the Wellcome Sanger Institute