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However, following exposure to stressors, Keap1 undergoes modifications that impair its ability to bind to and target Nrf2 for degradation

Stress-induced blood brain barrier disruption: molecular mechanisms and signaling pathways

AZM, acting potentially as both a senolytic and senomorphic (suppressing IL-6 SASP factor), also showed beneficial effects in a mouse model of endometriosis [55]

Mulcahy, R.T., et al., Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

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10.1016/j.bpobgyn.2008.10.008 115 PappasR