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The N-terminal periplasmic domains also interact with the components of the cytoplasmic membrane-embedded platform of the secretion machinery, to promote channel opening, cargo docking, and subsequent release 26,27

Furthermore, through DTI, neuronal circuits activated during a task were found to have increased levels of myelination in seniors, showing the ability for activity-dependent myelination in the aged human brain (Scholz et al., 2009

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