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Previous studies have shown that HFD-fed animals with T2DM show significant liver steatosis and decreased liver extract fraction

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235 Procyanidins support gutliver axis function by upregulating tight junction proteins (e.g., zonula occludens-1, claudin-1), limiting endotoxin translocation, and protecting the liver from endotoxemia and inflammation

We found using Uniprot annotation that 75% of the human hit proteins contained a phosphorylation site compared to 64% for total proteins

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