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De Rossi, F

Keeping HbA1c below 7% slows progression, and tighter control may allow repair processes, including peptide-supported repair, to operate effectively

Annu Rev Plant Physiol Plant Mol Biol 41:225253

The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)