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The loading phase delivers higher doses to saturate tissues rapidly

10.1016/0005-2795(77)90051-4 84 BurzlaffN

Separately, Klothea Bio launched in November 2024 pursuing an mRNA-based approach to enhance endogenous klotho production

While our nested casecontrol design, PSM analyses, dynamic PDC-based exposure assessment, and subgroup analyses help mitigate these concerns, they cannot fully eliminate them

Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo