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At 24 h, the upregulation of HMOX1 and GADD45B remained significant in both cell types, but DNAJB1 regulation declined and was no longer significant in HepG2 ATP7B-KO cells

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As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively

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