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This absence of foundational pharmacokinetic information constitutes a major knowledge gap with direct implications for clinical application, dosing strategies, and safety monitoring
Estas dosis provienen de estudios preclnicos publicados
38 It is known, however, that the major zinc-sensing transcription factors in eukaryotic cells, exemplified by vertebrate MTF-1 and Zap1p in Saccharomyces cerevisiae (Figure 3B) employ one or more ZF motifs as sensors of cellular zinc status, which results in the regulation of transcription of genes that encode enzymes that re-establish zinc homeostasis
[DOI] [PubMed] [Google Scholar] 40.Medvidovic-Grubisic M., Stambolija V., Kolenc D., Katancic J., Murselovic T., Plestina-Borjan I., Strbe S., Drmic D., Barisic I., Sindic A., et al
