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Attempts to reclassify injectable B12 to a Pharmacy (P) or General Sales List (GSL) medicine have consistently met resistance from the Medicines and Healthcare products Regulatory Agency and the government, based on two key legal criteria outlined in the Human Medicines Regulations 2012 : 1

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The chi-square test of independence or Wilcoxon rank sum test was utilized to compare the incidence ratios of penetration into the intradeltoid muscle across various needle penetration depths