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These translational findings are an outgrowth of a mechanistic model in rodents with impaired plasticity of key brain areas relevant to mood, cognitive and other main disorders, wherein LAC levels are markedly decreased and signal abnormal brain and systemic functions
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These compounds neutralize highly reactive free radicals, which are generated as natural byproducts of metabolism or through external sources such as UV radiation, pollution, and certain medications
Moreover, MZB entry and retention in the splenic marginal zone are tightly regulated by chemotactic molecules, such as C-X-C Motif Chemokine Ligand 13 (CXCL13) and sphingsoine-1-phosphate (S1P) 54
