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placebo 18 1.29) for the two treatment groups

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. Doctors may not be prescribing oral vitamin B12 formulations because they may be unaware of this option or have concerns regarding its effectiveness Objectives: To assess the effects of oral vitamin B 12 versus intramuscular vitamin B 12 for vitamin B 12 deficiency. Selection criteria: Randomized controlled trials (RCTs) comparing the effect of oral versus IM vitamin B 12 for vitamin B 12 deficiency

A modified analog (CB4211) showed good tolerability in a Phase 1 trial [7]

The same 10 mg vial targeting 5 mg/mL needs 2.0 mL, while targeting 2.5 mg/mL requires 4.0 mL