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The effect of the latter compound is present only at low concentrations

658 Likewise, expression of glutamate transporters is reduced in astrocytes from human tissue and animal models of HD 112,659

However, prospective validation and outcome-based thresholds are required before routine clinical adoption

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The association of IGF-1 and IGF-1R apparently leads to changes in metabolism, prevention of cell death (apoptosis), promotion of cell growth (hypertrophy), differentiation and cell division (hyperplasia), normal development, and even malignant growth