doi: 10.1080/09593330.2015.1075599
The GLP-1 receptor, already operating at a structural disadvantage (higher EC50), may fall below the threshold for clinically significant activation
According to the Mayo Clinic, some of these possible interactions include: Substrates for cytochrome P450 2C9, such as Valium (diazepam) and Jantoven (warfarin) Some diabetes medications Evista (raloxifene) Olysio (simeprevir) Rapamune (sirolimus) Other medications, such as those that treat allergies, high cholesterol, anxiety, and cancer, could also interact with milk thistle, according to Mount Sinai
& Sixto-Leal, C
Izzo JG, Malhotra U, Wu TT, Luthra R, Correa AM, Swisher SG , Hofstetter W, Chao KS, Hung MC, Ajani JA
A pharmacology that keeps amylin receptors tonically engaged, day and night, may reproduce amylins central appetite effects (which appear to tolerate sustained stimulation reasonably well) while behaving quite differently at the level of the stomach, where continuous braking could invite adaptive counter-regulation
