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2.4 Integration of gut, brain, and kidney signals The gut-brain-kidney axis is closely linked to the development and progression of several specific diseases, with each organ system influencing the others in ways that can exacerbate or mitigate these conditions, including CKD (Figure 2), hypertension, irritable bowel syndrome, and kidney stones

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Reactive oxygen species (ROS) are generated as byproducts during thyroid hormone synthesis [12]

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