Four main MAPK cascades have been identified: ERK1/2 (extracellular signal-regulated kinases), c-Jun N-terminal kinases (JNK), p38 (p38 kinase), and the BMK1/ERK5 (big MAP kinase 1) (Schaeffer and Weber 1999)
Subsequently, this effect is reversed by the decreasing Nrf2 levels in the nucleus (nNrf2), leading to a decreased Keap1 level that is accompanied by a recovery of unbound Nrf2 because of a decreased sequestration in complexes with Keap1 (Fig 3C
falciparum doubles hepcidin concentrations, impairing iron absorption and utilisation (appendix p
Blood 99 , 26122614 (2002)
Further research is required to fully elucidate the KEAP1-dependent and -independent mechanisms of GSH-dependent regulation of NRF2
H.GallandA.TsikasD.FrolichJ