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[PMC free article: PMC5117680] [PubMed: 27842768] (Review of the frequency, clinical features, patterns of injury and outcomes of HDS hepatotoxicity with specific mention of anabolic steroids, black cohosh, germander, green tea, kava, pyrrolizidine alkaloids and proprietary multiingredient nutrition supplements [MINS])

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Also, during recovery from endurance exercise, BCAAs were found to have anabolic effects in human muscle

178 (1 Pt 1): 1615

Dureau P, Broyer M, Dufier JL (2003) Evolution of ocular manifestations in nephropathic cystinosis: a long-term study of a population treated with cysteamine

These safety limitationsparticularly the potential for hepatorenal toxicity, mitochondrial dysfunction, and off-target metabolic effectshave underscored the critical need for well-tolerated (Pernicova and Korbonits, 2014), organ-sparing therapeutic alternatives (Table 1)