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National Academies Press (US).

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Intermediates of the TCA cycle such as -ketoglutaric acid and citrate typically show decreased levels, whereas succinate is upregulated in RA (45, 46)

Injectable users rarely experience these effects at standard therapeutic doses

The epidemiological data on sex differences in acetaminophen-induced liver injury in humans is inconsistent, which can be attributed to confounding factors such as variations in age, dosage, time elapsed from ingestion to hospitalization, and time from ingestion to N-acetylcysteine administration