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Research has identified coffee-specific catechols as a contributing factor in coffee-induced gastric acid secretion that persists even in decaffeinated and low-CGA preparations which is why some individuals report stomach sensitivity to coffee even after eliminating caffeine and reducing CGA exposure [ 3 ]

Aug 2011;109(2):275-281

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Immunohistochemistry analysis indicated that chemotherapy-resistant patients had significantly higher expression levels of NRF2, GPX4 and SOD1 in tumor tissues compared to the sensitive ones

Trends Pharmacol Sci 32:8289 Touyz RM, Schiffrin EL (2000) Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells