ALA may rescue chemotherapy-induced mitochondrial toxicity to exert neuroprotective effects, but because of the differences in its in vivo experimental findings, future studies of ALA as a potential prevention of CIPN should not be ignored, while other exogenous antioxidant supplements, such as mineral elements, phytochemicals (curcumin and hesperidin), nutritional antioxidants, cytoprotectants and synthetic compounds, have very promising results in basic research
J Neuropsychiatry Clin Neurosci
Focusing on such molecules, along with promising therapeutic candidates like Epigallocatechin gallate and tofacitinib, offers encouraging strategies for targeted interventions in RM (Xie et al., 2024)
However, it is known that through dietary intake and/or supplementation, antioxidants such as vitamin C, E, and carotenoids are deposited into the epidermis at higher concentrations compared with the dermis [4,5,6], which suggests the importance of inside to outside treatment of the skin
Even if a direct cause-and-effect link exists, it is difficult to prove whether higher or lower RAS contributes to increased suicide risk
Two mild anaphylactoid reactions and one severe anaphylactic reaction, including laryngospasm, were reported after intravenous lipoic acid administration (55)
