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BAs and UC In general, there is a balance between PBA and SBA, but gut microbiota dysbiosis disrupts it, and studies have shown that fecal PBA concentrations in UC patients are significantly higher than those in normal people, whereas SBA concentrations are significantly lower than those in normal people[107 ]

Ultimately, this results in a reduction of fatty acid release, further exacerbating disturbances in lipid metabolism ( 2.2.2 The impact of ROS on mitochondria Mitochondrial dysfunction is a critical pathological component in the mechanism of cellular damage associated with insulin resistance