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Sirtuin 1 (SIRT1) deacetylates nuclear factor kappa-light-chain-enhancer of activated cells (NF-kB), forkhead box O (FOXO), and PGC-1 and subsequently initiates oxidative metabolism in mitochondria and to suppress ROS production

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Lipids There is a generation of ROS due to the intake of polyunsaturated fatty acids which are neutralized by vitamins C and E and carotenoids

Yu BP, Yang R (1996) Critical evaluation of the free radical theory of aging