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Always use a broad-spectrum SPF 30+ daily, and discontinue use temporarily if experiencing significant redness, peeling, or discomfort.

A.AbbottG.et al (2016)

10.1136/gut.2006.101634 Gut 19 MalfertheinerP.MegraudF.OMorainC.GisbertJ.KuipersE.AxonA.et al (2017)

While evidence supporting specific multi-hormone combinations is limited, this approach is widely used in clinical practice when single-agent commercial products would require the patient to use multiple separate products

But losing 10-15% to freeze damage may be preferable to losing 70% to expiration at room temperature or refrigeration beyond 30 days