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Key Endpoints in Translational Diet-induced Obese Rodent Models Diet-induced obese (DIO) mice and rats represent the standard translational obesity models in preclinical drug discovery, where excessive caloric intake and the drive for weight regain plays a major role in the etiology, pathology and progression of the disease
A common dysfunctional variant of ABCG2 (Q141K, rs2231142) significantly accelerates the onset of gout while delaying that of PD [25]
Both eventually reach similar endpoints
(PubMed) Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I
It strengthens hair follicles, extends the anagen (growth) phase, and improves outcomes following hair transplantation