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This suggests a potential new cancer treatment strategy by converting a cold tumor into a hot tumor, which could enhance the delivery of drugs and antibodies in CRC gene immunotherapy [169]

Funding This work was funded by Fondecyt de Inicio grant No 11200798 and Fondecyt Regular grant No 1201283

Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease

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This dampening of the HPA stress response occurs without suppressing normal cortisol rhythms, suggesting that DSIP acts as a modulator rather than an inhibitor of stress signalling

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