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Excessive excitation can promote anxiety-like behavior because of increased excitatory transmission or decreased inhibitory transmission, and its imbalance leads to the disorder of amygdala neural circuit (Wu et al., 2008)

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Molecular patterns associated with microbes (MAMPs), which we can detect circulating in IBD, might activate immune responses as well as T cells, osteocytes, osteoblasts, and osteoclasts located in the bone marrow, which leads to low bone formation and high resorption (240)

10.1093/oxfordjournals.jbchem.a135625 J

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