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Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels

This is why growth hormone therapy requires monitoring blood sugar and sometimes necessitates diabetes medication adjustments

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Used For: Physician-directed treatment support

William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

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